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HILESTROL TM (BPF)  is a concentrated polyphenolic fraction derived from the fruit of the bergamot plant, which is a type of citrus fruit grown in the Calabria region of southern Italy. Hilestrol has been shown to have numerous health benefits, including the ability to improve lipid profile.

Studies have shown that Hilestrol can improve lipid profile by reducing total cholesterol, low-density lipoprotein (LDL) cholesterol (also known as "bad" cholesterol), and triglyceride levels, while increasing high-density lipoprotein (HDL) cholesterol (also known as "good" cholesterol) levels.

One study found that Hilestrol supplementation significantly reduced total cholesterol, LDL cholesterol, and triglycerides in patients with high cholesterol levels. Another study found that Hilestrol supplementation improved lipid profile in patients with metabolic syndrome, a cluster of conditions that increase the risk of cardiovascular disease.

HILESTROL TM is thought to work by inhibiting the activity of an enzyme called HMG-CoA reductase, which is involved in cholesterol synthesis. Hilestrol may also increase the expression of genes involved in cholesterol metabolism and transport, leading to improved lipid profile. Statins are a commonly prescribed medication for treating hyperlipidemia, but they may not be effective for all patients or may cause side effects.

HILESTROL TM works synergistically with statins by targeting different pathways involved in lipid metabolism. For example, statins primarily inhibit the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis, while Hilestrol may inhibit the absorption of cholesterol from the diet and enhance the clearance of cholesterol from the blood.

Overall, Hilestrol appears to be a promising natural supplement for improving lipid profile and reducing the risk of cardiovascular disease.